When picking or editing a gaming or anime PFP, focus on a clean face crop and a...

https://purepfp.com/why-bold-game-characters-remain-recognisable-in-tiny-profile-icons/

When picking or editing a gaming or anime PFP, focus on a clean face crop and a strong silhouette so the key features stand out even small and round. Use high contrast colors and keep the background simple—avoid text or busy details