You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://travishwsd389.pinehavenscope.com/posts/the-best-materials-for-permanent-rodent-exclusion-in-san-diego-homes-2

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.